Bioinformatician in Newcastle upon Tyne - CV-Library

Exciting Medical Devices Development company seeks an experienced Bioinformatician.

About the role:

The Bioinformatician will work within the Assay Team to develop point of care molecular diagnostic assays and associated technologies. It is an opportunity for candidates with a strong background in sequence-based bioinformatics to contribute on projects leading to the development of diagnostic assays.

Duties may include:

Work within the Assay Team to deliver molecular diagnostic product pipeline.
Identify appropriate reference sources for sequences, for example public sources such as GISAID and NCBI databases.
Familiar with NextGen sequencing and associated pipelines.
Collate and annotate reference sequences across multiple microorganisms.
Be confident using python and Jupyter Lab books as a working and application development environment along with GIT as a version control system.
Generate, record, manipulate, analyse and present complex data to line manager, colleagues, senior management and external partners.
Maintain records, logs and or databases of analyses for regulatory reporting purposes.
Interrogate sequence data to design new diagnostic assays, applying assay team lead rules (e.g. Tm, primer length, GC ratio) to shortlist targets for experimental testing.
Undertake in silico inclusivity and exclusivity testing and analyse homology to confirm target suitability.
Undertake periodic in silico review of existing assay designs to confirm ongoing suitability of the assay for VOC, VUI and variants being monitored.
Work on collaborative projects with external partners and be point of contact for bioinformatics.
Work within the quality systems following GDP and ISO 13485 standards.Skills and experience:

MSc degree or equivalent in a relevant subject (i.e. bioinformatics, computer science or statistics).
Relevant experience in bioinformatics with a strong knowledge of microbial genomics.
Familiarity with sequencing data (Sanger and NGS) and standard bioinformatics tools (alignment, variant calling, assembly etc.)
Experience in data manipulation and analysis of large genomic datasets.
Knowledge and competence in Python, Docker, Git, Linux, MySQL or similar software development tool.
Knowledge of nucleic acid amplification and detection chemistries.
Ability to work to the Quality Management Systems in line with ISO13485 standards.
Hands on experience with the manipulation and development of PCR chemistries for diagnostic tests.
GPU programming.
Eligible to work full time in the UK without restriction.Apply now for more information